Name | Type | Posted | Actions |
|---|---|---|---|
Att D - VOLUME2_PRICE-COST PROPOSAL WORKBOOK (Resource Sharing) CIRCLE_Amend 04.xlsx | XLSX | May 21, 2026 | |
ARPA-H-SOL-26-139_Amendment 04.docx | DOCX | May 21, 2026 | |
ARPA-H-SOL-26-139_Amendment 03.pdf | Apr 28, 2026 | ||
Att B - VOLUME 1_TECH-MANAGEMENT.pdf | Mar 23, 2026 | ||
ARPA-H-SOL-26-139_Amendment 02.pdf | Mar 23, 2026 | ||
ISO Amd 1 - CIRCLE.pdf | Feb 20, 2026 | ||
Att F - VOLUME 3_Administrative and National Policy - CIRCLE.docx | DOCX | Feb 17, 2026 | |
ISO - CIRCLE.pdf | Feb 17, 2026 | ||
Att E - VOLUME 3_Model OT Agreement - CIRCLE.docx | DOCX | Feb 17, 2026 | |
Att C - VOLUME 1_Task Description Document - CIRCLE.docx | DOCX | Feb 17, 2026 | |
Att A - Solution Summary Template - CIRCLE.docx | DOCX | Feb 17, 2026 | |
Att D - VOLUME 2_PRICE-COST PROPOSAL WORKBOOK - (Resource Sharing) - CIRCLE.xlsx | XLSX | Feb 17, 2026 | |
Att B - VOLUME 1_TECH - MANAGEMENT - CIRCLE.docx | DOCX | Feb 17, 2026 |
Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Innovative Solutions Opening (ISO)
Contact and place of performance
ARPA-H RSO CIRCLE ISO Coordinator
USA
Responses to all questions received have been posted on the CIRCLE program page. At this time, additional questions will not receive responses. The Advanced Research Projects Agency for Health (ARPA-H) is posting this Innovative Solutions Opening (ISO) solicitation in support of the Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Program. ARPA-H anticipates that multiple...
View moreFull Proposals Due: Thursday, May 28, 2026, 1 PM ET (to https://solutions.arpa-h.gov)
ARPA-H will not reimburse potential proposers for time and effort related to submission of solution summaries or proposals. When planning a response to this notice, proposers should consider that some parts of the submission process may take from one business day to one month to complete.
-------------------------- Amendment 1 --------------------------
The purpose of this amendment is to: change the proposal submission date to Thursday, May 28, 2026 and replace Office of Commercialization (OC) with ARPA-H.
-------------------------- Amendment 2 --------------------------
The purpose of this amendment is to provide revisions as highlighted in yellow in the attached documents.
-------------------------- Amendment 3 --------------------------
The purpose of this amendment is to provide revisions as highlighted in yellow in the attached documents.
-------------------------- Amendment 4 --------------------------
The purpose of this amendment is to provide revisions as highlighed in yellow in the attached documents.
The Advanced Research Projects Agency for Health (ARPA-H) is soliciting proposals for the Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) program. This initiative seeks to develop a critical illness Control Point Validation Engine to improve intensive care unit health outcomes and reduce stay times and costs by assessing, predicting, and treating immuno-inflammatory dysregulation before it leads to organ failure. ARPA-H anticipates awarding multiple Other Transaction Agreements to support these research and development objectives.
This solicitation is identified as ARPA-H-SOL-26-139 and falls under NAICS code 541715 for Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) and PSC AN13 for HEALTH R&D SERVICES; HEALTH CARE SERVICES; EXPERIMENTAL DEVELOPMENT. There is no set-aside for this requirement, identified as NONE. The place of performance is the United States, and the primary point of contact is the ARPA-H RSO CIRCLE ISO Coordinator.
The schedule for this opportunity includes a solution summary deadline of March 30, 2026, followed by a final full proposal deadline of May 28, 2026. The solicitation includes 13 total attachments, such as technical management templates, price-cost proposal workbooks, and four amendments that provide highlighted revisions to the program documentation. All work under the resulting agreements will focus on experimental development and health care research services.
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