Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Innovative Solutions Opening (ISO)

The Advanced Research Projects Agency for Health (ARPA-H) is soliciting proposals for the Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) program. This initiative seeks to develop a critical illness Control Point Validation Engine to improve intensive care unit health outcomes and reduce stay times and costs by assessing, predicting, and treating immuno-inflammatory dysregulation before it leads to organ failure. ARPA-H anticipates awarding multiple Other Transaction Agreements to support these research and development objectives.

This solicitation is identified as ARPA-H-SOL-26-139 and falls under NAICS code 541715 for Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) and PSC AN13 for HEALTH R&D SERVICES; HEALTH CARE SERVICES; EXPERIMENTAL DEVELOPMENT. There is no set-aside for this requirement, identified as NONE. The place of performance is the United States, and the primary point of contact is the ARPA-H RSO CIRCLE ISO Coordinator.

The schedule for this opportunity includes a solution summary deadline of March 30, 2026, followed by a final full proposal deadline of May 28, 2026. The solicitation includes 13 total attachments, such as technical management templates, price-cost proposal workbooks, and four amendments that provide highlighted revisions to the program documentation. All work under the resulting agreements will focus on experimental development and health care research services.