Resilient Systems Office (RSO) Mission Office Innovative Solutions Opening (ISO)

The Advanced Research Projects Agency for Health (ARPA-H) issued this Innovative Solutions Opening (ISO) to solicit projects supporting the Resilient Systems Office (RSO). This mission office focuses on systemic challenges within the healthcare and public health landscape by investing in technologies that address gaps in the quality, efficacy, and consistent availability of care. Performance is located in the USA under NAICS 541715 for Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) and PSC AN13 for Health R&D Services, Health Care Services, and Experimental Development.

The solicitation utilizes a multi-step submission process including solution summaries and full proposals. Amendment 3, effective immediately, introduced several administrative and policy updates, including revised Organizational Conflicts of Interest affirmations, research security disclosures, and intellectual property data assertion charts. Financial reporting requirements were also modified, specifically increasing the threshold for supporting documentation on planned materials and equipment purchases from $5,000 to $10,000 per unit. Furthermore, the amendment updated requirements regarding human and animal subjects research, biosecurity protocols, and labor rate definitions within cost proposal documents.

This solicitation, identified by number ARPA-H-SOL-24-103, has a response deadline of March 6, 2029. Documentation for the opportunity includes 13 attachments, featuring updated solution summary templates, cost proposal workbooks, and administrative requirement guides. All submissions and inquiries are managed through the agency's dedicated solutions portal. Submissions made prior to the most recent amendment are evaluated under previous versions of the solicitation, while new proposals following existing solution summaries must adhere to the current Amendment 3 standards.