Proactive Health Office (PHO) Mission Office Innovative Solutions Opening (ISO)

The Advanced Research Projects Agency for Health (ARPA-H) Proactive Health Office (PHO) is seeking innovative solutions to improve the healthspan and health outcomes of Americans prior to the onset of disease or diminished quality of life. This solicitation, identified by number ARPA-H-SOL-24-106, focuses on population-level improvements in disease prevention, wellness-promoting behaviors, novel early-detection methods, and prophylactic interventions. The agency aims to identify system-level innovations required for the effective delivery of proactive health across the United States.

Classified under NAICS 541715 for Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) and PSC AN13 for Health R&D Services, Health Care Services, and Experimental Development, this solicitation remains open for responses until March 6, 2029. Interested parties may submit solution summaries, questions, or formal proposals through the ARPA-H Solutions Site. As of the June 10, 2026, update, Amendment 4 is in effect, which includes updated administrative and national policy requirements and revised research security disclosure language.

The procurement includes 18 total attachments, including various bundles of attachments and submission portals for solution summaries and proposals. Entities that previously submitted both a solution summary and a proposal are not required to take further action, though any new proposals following a prior solution summary must comply with the updated terms in Amendment 4. All performance will take place within the United States.