Intelligent Generator of Research (IGoR)

The Advanced Research Projects Agency for Health (ARPA-H), within the National Institutes of Health, is soliciting proposals for the Intelligent Generator of Research (IGoR) program. This initiative seeks to eliminate research inefficiencies and accelerate therapy development for complex diseases through an AI-enabled interoperable research ecosystem. The program focuses on developing mechanistic disease models that encode causal biological relationships, an AI orchestration layer for identifying knowledge gaps and designing experiments, a layered protocol architecture for reproducible experimentation, and a distributed marketplace of validated laboratories providing standardized data. These components are intended to create a cycle of hypothesis generation and model refinement that produces validated knowledge significantly faster than conventional methods.

This solicitation is identified under number ARPA-H-SOL-26-155 and is classified under NAICS code 541715 for Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) and PSC code AN13 for Health R&D Services; Health Care Services; Experimental Development. There is no set-aside designated for this procurement. The government intends to host a hybrid Proposers Day in the Washington, D.C. metro area in early June 2026 to provide further information regarding the program's objectives.

Responses to this solicitation are due by August 6, 2026, for performance within the United States. The notice includes 12 attachments, such as technical and management proposal templates, price proposal spreadsheets, a task description document, solution summary instructions, and a draft model Other Transaction (OT) agreement. Recent updates to the solicitation include revisions to the solution summary instructions and the addition of the draft model OT agreement. The primary point of contact for this effort is the IGoR ISO.