Immune Mechanisms of Protection Against Mycobacterium tuberculosis Center (IMPAc-TB)

This solicitation will require the use of human samples and/or clinical studies, at least one animal model, and computational data integration and modeling for cross-comparative analyses of the human and animal studies. These requirements are in alignment with NIH’s initiative to prioritize human-based research (NIH Funding Announcements to Align with NIH Initiative to Prioritize Human-based Research | Grants & Funding). In addition, investigators may consider using new approach methods (NAMS) such as organoid or other ex vivo systems to assess human immunity to Mtb or TB vaccines. This program will help identify signatures associated with risk or protection from disease/infection and identify and evaluate protective antigens/immune epitopes. The identification of immune epitopes within the IMPAc-TB program is complementary to the DAIT Immune Epitope Discovery programs, and NIAID Program will foster cross-collaborative activities. In addition, the initiative will support translation of knowledge gained about tissue-specific immune responses to advance vaccine approaches (including mucosal vaccine approaches). IMPAc-TB will support the refinement of fit-for-purpose animal models for testing vaccine candidates targeting different stages of TB disease and emerging technologies such as tissue-based models, and computational modeling for cross-species analyses. Clinical research will also be supported through clinical cohorts or clinical trials using novel vaccine candidates and will enable backtranslation to animal models.

To facilitate cross-contract collaborative studies and activities, each contractor will set aside from their individual budget, $300,000/year in total costs starting in years two through five of the contracts. These funds will be used to support small-scale studies and/or other activities.  Do not propose cross-contract collaborative studies/activities in the proposal. The cross-contract collaborative studies will be proposed starting in year two of the contract by each IMPAc-TB contractor. The proposed cross-contract collaborative studies will be evaluated by NIH Program staff, the PI(s) of each IMPAc-TB contract, and the External Scientific Advisory Group (ESAG).  The final selection of the cross-contract collaborative study will be made by NIH.

It is anticipated that two to three cost reimbursement, completion type contracts will be awarded with performance beginning about September 1, 2027. NIAID estimates that the average annual total cost (direct and indirect costs combined) for the entire program will be $10.5 million. However, it is anticipated that the total cost for each award may vary depending upon the scope of the project and the technical objectives and will be approximately $5 million total costs per year. The length of time for which funding is requested should be consistent with the nature and complexity of the proposed research and should not exceed five years.

Any responsible offeror may submit a proposal which shall be considered by the Agency. This BAA will be available electronically on/about June 2, 2026, and may be accessed through SAM.gov. This notice does not commit the Government to award a contract. No collect calls will be accepted. No facsimile transmissions will be accepted.

For this solicitation, the NIAID requires proposals to be submitted via the NIAID electronic Contract Proposal Submission (eCPS) website. Submission of proposals by facsimile or e-mail is not acceptable.

For directions on using eCPS, go to the website https://ecps.nih.gov/ and then click on "How to Submit."