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Award ID | Description | Recipient | Total Value | Awarding Agency | Funding Agency | Set Aside | NAICS | PSC | Award Date | Start Date | End Date | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TUITION AND FEES | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $42,374 | DEPT OF THE NAVY | DEPT OF THE NAVY | — | 611310Colleges, Universities, and Professional Schools | U005EDUCATION/TRAINING- TUITION/REGISTRATION/MEMBERSHIP FEES | Jan 29, 2026 | Jan 29, 2026 | Jun 30, 2026 | ||
| NY, CORNELL UNIVERSITY FALL 1301264268 | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $42,374 | DEPT OF THE NAVY | DEPT OF THE NAVY | — | 611310Colleges, Universities, and Professional Schools | U005EDUCATION/TRAINING- TUITION/REGISTRATION/MEMBERSHIP FEES | Jul 8, 2025 | Aug 1, 2025 | Dec 31, 2025 | ||
| TUITION AND FEES | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $38,000 | DEPT OF THE NAVY | DEPT OF THE NAVY | — | 611310Colleges, Universities, and Professional Schools | U005EDUCATION/TRAINING- TUITION/REGISTRATION/MEMBERSHIP FEES | Feb 26, 2025 | Feb 27, 2025 | May 30, 2025 | ||
| TUITION AND FEES | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $40,201 | DEPT OF THE NAVY | DEPT OF THE NAVY | — | 611310Colleges, Universities, and Professional Schools | U005EDUCATION/TRAINING- TUITION/REGISTRATION/MEMBERSHIP FEES | Aug 8, 2024 | Aug 8, 2024 | Dec 31, 2024 | ||
| 22-22SBR_2-0025 SPACEFLIGHT AND REGOLITH INDUCED MITOCHONDRIAL STRESS MITIGATED BY MIRNA-BASED COUNTERMEASURES | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $60,000 | NATIONAL AERONAUTICS AND SPACE ADMINISTRATION | NATIONAL AERONAUTICS AND SPACE ADMINISTRATION | — | — | AJ11GENERAL SCIENCE AND TECHNOLOGY R&D SERVICES; GENERAL SCIENCE AND TECHNOLOGY; BASIC RESEARCH | Jun 24, 2024 | Apr 22, 2024 | Apr 21, 2026 | ||
| LEVERAGING THE MICROBES OF EARTHS EXTREME ENVIRONMENTS FOR SUSTAINABLE PLANT GROWTH IN LUNAR REGOLITH | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $300,000 | NATIONAL AERONAUTICS AND SPACE ADMINISTRATION | NATIONAL AERONAUTICS AND SPACE ADMINISTRATION | — | — | AJ11GENERAL SCIENCE AND TECHNOLOGY R&D SERVICES; GENERAL SCIENCE AND TECHNOLOGY; BASIC RESEARCH | Mar 22, 2024 | Feb 16, 2024 | Feb 15, 2027 | ||
| DATASET DELIVEABLE POPULATION-BASED EPIDEMIOLOGIC STUDY OF NEW YORK, NY PERTAINING TO NON-TUBERCULOUS MYCOBACTERIAL PULMONARY DISEASE | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $18,000 | NATIONAL INSTITUTES OF HEALTH | NATIONAL INSTITUTES OF HEALTH | — | 518210Computing Infrastructure Providers, Data Processing, Web Hosting, and Related Services | B506SPECIAL STUDIES/ANALYSIS- DATA (OTHER THAN SCIENTIFIC) | Sep 14, 2023 | Sep 20, 2023 | Nov 30, 2023 | ||
| 19-19HCBPSR_2-0067, THE IMPACT OF SPACEFLIGHT AND RADIATION ON CLONAL HEMATOPOIESIS | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $488,896 | NATIONAL AERONAUTICS AND SPACE ADMINISTRATION | NATIONAL AERONAUTICS AND SPACE ADMINISTRATION | — | — | AR11SPACE R&D SERVICES; SPACE FLIGHT, RESEARCH AND SUPPORTING ACTIVITIES; BASIC RESEARCH | May 3, 2023 | May 1, 2023 | Apr 30, 2027 | ||
| TO PREPARE FOR FUTURE HUMAN EXPLORATION MISSIONS FAR FROM EARTH, NASA S SPACE BIOLOGY PROGRAM IS SEEKING TO BUILD A BETTER UNDERSTANDING OF THE EFFECTS OF SPACEFLIGHT AND ZERO GRAVITY ON THE BIOLOGY OF MICROORGANISMS, PLANTS AND ANIMALS IN SPACECRAFT | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $744,429 | NATIONAL AERONAUTICS AND SPACE ADMINISTRATION | NATIONAL AERONAUTICS AND SPACE ADMINISTRATION | — | — | AJ11GENERAL SCIENCE AND TECHNOLOGY R&D SERVICES; GENERAL SCIENCE AND TECHNOLOGY; BASIC RESEARCH | Jan 25, 2022 | Jan 25, 2022 | Nov 30, 2024 | ||
| OUR PROPOSED EXPERIMENTS WILL ENHANCE OUR UNDERSTANDING OF SPACEFLIGHT-INDUCED GENE EXPRESSION CHANGES BY PERFORMING SINGLE-CELL RNA-SEQUENCING AND SPATIAL RNA-SEQUENCING ON MOUSE TISSUES FROM SPACEFLIGHT EXPERIMENTS. | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $139,820 | NATIONAL AERONAUTICS AND SPACE ADMINISTRATION | NATIONAL AERONAUTICS AND SPACE ADMINISTRATION | — | — | AJ11GENERAL SCIENCE AND TECHNOLOGY R&D SERVICES; GENERAL SCIENCE AND TECHNOLOGY; BASIC RESEARCH | Jan 11, 2021 | Feb 1, 2021 | Jan 31, 2024 | ||
| TUBERCULOSIS TRIALS AND CONSORTIUM SERVICES | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $5,917,206 | CENTERS FOR DISEASE CONTROL AND PREVENTION | CENTERS FOR DISEASE CONTROL AND PREVENTION | — | 541714Research and Development in Biotechnology (except Nanobiotechnology) | AN12HEALTH R&D SERVICES; HEALTH CARE SERVICES; APPLIED RESEARCH | Dec 18, 2020 | Jan 1, 2021 | Dec 31, 2030 | ||
| THE IMPACT OF HUMAN SPACEFLIGHT ON CLONAL HEMATOPOIESIS | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $20,000 | NATIONAL AERONAUTICS AND SPACE ADMINISTRATION | NATIONAL AERONAUTICS AND SPACE ADMINISTRATION | — | — | AR21 | Sep 26, 2020 | Oct 1, 2020 | Sep 30, 2021 | ||
| NEXTGEN LIBRARY PREPARATION&SEQUENCING | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $52,780 | DEPT OF THE NAVY | DEPT OF THE NAVY | — | 611310Colleges, Universities, and Professional Schools | U008EDUCATION/TRAINING- TRAINING/CURRICULUM DEVELOPMENT | Sep 21, 2020 | Sep 16, 2020 | Nov 20, 2020 | ||
| BAA-19-00123 - PMWP#132 - DEVELOPMENT OF RABBIT ANIMAL MODELS OF VENTILATOR-ASSOCIATED BACTERIAL PNEUMONIA PRODUCED BY CARBAPENEM-RESISTANT PSEUDOMONAS AERUGINOSA AND ACINETOBACTER BAUMANNII | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $994,896 | FOOD AND DRUG ADMINISTRATION | FOOD AND DRUG ADMINISTRATION | — | 541990All Other Professional, Scientific, and Technical Services | B504SPECIAL STUDIES/ANALYSIS- CHEMICAL/BIOLOGICAL | Sep 14, 2020 | Sep 14, 2020 | Jun 30, 2023 | ||
| ISOFORM REPERTOIRE ANALYSIS OF PBMCS IN PATIENTS WITH UVEITIS POP: 9/1/2020-8/31/2021 | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $0 | NATIONAL INSTITUTES OF HEALTH | NATIONAL INSTITUTES OF HEALTH | — | 541990All Other Professional, Scientific, and Technical Services | R499SUPPORT- PROFESSIONAL: OTHER | Jul 20, 2020 | Jul 20, 2020 | Aug 31, 2021 | ||
| DNA SAMPLES SERVICE PR# 69-4332-19 | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $61,500 | DEPT OF THE NAVY | DEPT OF THE NAVY | — | 611310Colleges, Universities, and Professional Schools | U008EDUCATION/TRAINING- TRAINING/CURRICULUM DEVELOPMENT | Sep 30, 2019 | Sep 30, 2019 | Jan 28, 2020 | ||
| HUMAN WHOLE GENOME SEQUENCING | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $149,600 | FOOD AND DRUG ADMINISTRATION | FOOD AND DRUG ADMINISTRATION | — | 541380Testing Laboratories and Services | B504SPECIAL STUDIES/ANALYSIS- CHEMICAL/BIOLOGICAL | Jun 24, 2019 | Jun 24, 2019 | Jun 23, 2020 | ||
| TUITION AND FEES | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $32,975 | DEPT OF THE NAVY | DEPT OF THE NAVY | — | 611310Colleges, Universities, and Professional Schools | U005EDUCATION/TRAINING- TUITION/REGISTRATION/MEMBERSHIP FEES | Nov 26, 2018 | Jan 1, 2019 | Jun 30, 2019 | ||
| FRAMESHIFT PEPTIDE VACCINE FOR THE PREVENTION LYNCH SYNDROME-ASSOCIATED GASTROINTESTINAL CANCER HHSN2612015000391 TORFP: 2018-E12 POP: 9/17/2018 TO 3/16/2021 | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $891,984 | NATIONAL INSTITUTES OF HEALTH | NATIONAL INSTITUTES OF HEALTH | — | 541711 | AN11HEALTH R&D SERVICES; HEALTH CARE SERVICES; BASIC RESEARCH | Sep 13, 2018 | Sep 13, 2018 | Aug 16, 2023 | ||
| REFERENCING THE ATTACHED QUOTE BY DR. JENNY Z. XIANG - WEILL CORNELL MEDICINE WILL PROVIDE THE FOLLOWING SERVICES - SEQUENCING FOR ILLUMINA HISEQ4000 SEQUENCING PLATFORM - EXACTLY AS THE ATTACHED AUGUST 8, 2018 STATES - SHIP TO ADDRESS - USDA, ARS ROBERT W. HOLLEY CENTER 538 TOWER ROAD ATTENTION - DR. YIMIN XU ITHACA, NY 14853 ______________________________________________________________________________________________ PLEASE SUBMIT YOUR INVOICE - ELECTRONICALLY - THROUGH THE ATTACHED IPP VENDOR REGISTRATION WEB SITE INSTRUCTIONS. IPP HELP DESK PHONE NUMBER 1-866-973-3131 ______________________________________________________________________________________________ | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $14,060 | AGRICULTURAL RESEARCH SERVICE | AGRICULTURAL RESEARCH SERVICE | — | 518210Computing Infrastructure Providers, Data Processing, Web Hosting, and Related Services | B599SPECIAL STUDIES/ANALYSIS- OTHER | Aug 30, 2018 | Aug 30, 2018 | Sep 28, 2018 | ||
| TUITION AND FEES | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $32,975 | DEPT OF THE NAVY | DEPT OF THE NAVY | — | 611310Colleges, Universities, and Professional Schools | U005EDUCATION/TRAINING- TUITION/REGISTRATION/MEMBERSHIP FEES | May 15, 2018 | Jul 2, 2018 | Dec 31, 2018 | ||
| IGF::OT::IGF TUITION AND FEES | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $31,768 | DEPT OF THE NAVY | DEPT OF THE NAVY | — | 611310Colleges, Universities, and Professional Schools | U005EDUCATION/TRAINING- TUITION/REGISTRATION/MEMBERSHIP FEES | Oct 30, 2017 | Jan 1, 2018 | Jun 30, 2018 | ||
| IGF::OT::IGF YRG$S01140117 | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $34,027 | OFFICES, BOARDS AND DIVISIONS | OFFICES, BOARDS AND DIVISIONS | — | 541199All Other Legal Services | R424SUPPORT- PROFESSIONAL: EXPERT WITNESS | Jul 25, 2017 | Jul 26, 2017 | Dec 26, 2018 | ||
| IGF::OT::IGF TUITION AND FEES | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $31,768 | DEPT OF THE NAVY | DEPT OF THE NAVY | — | 611310Colleges, Universities, and Professional Schools | U005EDUCATION/TRAINING- TUITION/REGISTRATION/MEMBERSHIP FEES | Apr 12, 2017 | Jun 1, 2017 | Dec 31, 2017 | ||
| (1) SUMMARY MASSIVELY PARALLEL DNA SEQUENCING CONTINUES TO PROVIDE ASTONISHING INSIGHTS INTO THE REGULATORY COMPLEXITY OF THE MAMMALIAN GENOME, REVEALING HERITABLE AND DE NOVO OCCURRING RISK FACTORS PREDISPOSING HUMANS TO A WIDE VARIETY OF DISEASES AND DISORDERS. NOTABLY, MEMBERS OF THE ENCYCLOPEDIA OF DNA ELEMENTS (ENCODE) CONSORTIUM, INCLUDING CO-INVESTIGATORS DRS. MASON AND SNYDER, HAVE RECENTLY MAPPED THOUSANDS OF NON-CODING, REGULATORY ELEMENTS IN THE HUMAN GENOME THAT SPECIFY RISK AND PROTECTIVE SITES FOR MANY DISEASE. THESE NONCODING, GENETIC VARIATIONS ALSO SHOW DIFFERENTIAL IMPACT DEPENDING ON THE EPIGENETIC CHANGES OF THE GENOME, INCLUDING METHYLATION OF DNA AND CHROMATIN STATES INSIDE CELLS. YET, THESE QUESTIONS HAVE NOT BEEN COMPREHENSIVELY EXAMINED IN HUMAN ASTRONAUTS, DUE TO THE FACT THAT THE VERY FIRST DATA SETS THAT CAN DELINEATE THE PUTATIVE IMPACT OF GENOME-WIDE NONCODING VARIATION AND EPIGENETIC CHANGES FROM SPACE TRAVEL ARE ONLY NOW BEING GENERATED IN THE NASA TWINS STUDY. HOWEVER, WITH THIS DATA FROM NASA TWINS STUDY, THERE IS A UNIQUE OPPORTUNITY TO BOTH GENERATE NEW COMPUTATIONAL TOOLS FOR THE INTEGRATION OF THE DATA FROM THESE SAMPLES AND ALSO TO UTILIZE NOVEL, SINGLE-CELL APPROACHES FOR EPIGENETIC STATES IN THE HUMAN CELLS TAKEN FROM SPACE. WE PROPOSE TO EXPAND AND FURTHER INTEGRATE OUR TOOLS FOR EXAMINING THE REGULATORY CHANGES TO DNA AND RNA, TOGETHER CALLED "EPISUITE," WHICH WILL PROVIDE LONG-SOUGHT SOLUTIONS TO PROBLEMS IN INTEGRATIVE GENOMICS AND ESTABLISH A MORE SYSTEMS-LEVEL VIEW OF HUMAN PHYSIOLOGY DURING SPACE TRAVEL. SPECIFICALLY, WE WILL OPTIMIZE AND INTEGRATE OPEN-SOURCE AND PUBLISHED BIOINFORMATICS TOOLS BETWEEN BOTH LABORATORIES (HUGE-SEQ, METHYLKIT, EDMR, R-MAKE), EXPAND OUR CODE BASE WITH TWO NEW TOOLS (METHCLONE AND CEMBASE), AND THEN CREATE A WEB-INTERFACE FOR USERS TO UPLOAD, ORGANIZE, AND ANALYZE THESE DATA RELATIVE TO ENCODE PUBLIC DATA. THEN, WE WILL USE NOVEL SINGLE-CELL EXPERIMENTAL METHODS (SCATAC-SEQ) TO CONFIRM AND CHARACTERIZE THE IMPACT AND SCOPE OF SUCH NONCODING AND EPIGENETIC CHANGES. TOGETHER, THE DATA AND TOOLS IN EPISUITE, CONCOMITANT WITH THE NEW SINGLE-CELL CHROMATIN DATA, WILL ENABLE DISCOVERY AND VALIDATION OF SPECIFIC LOCI THAT REPRESENT THE GENETIC AND EPIGENETIC RISKS FACED BY ASTRONAUTS AND ALSO AN IMPROVED UNDERSTANDING OF THE REGULATORY AND GENETIC IMPACT (BMED5) OF THESE MOLECULAR CHANGES. (2) HYPOTHESIS WE HYPOTHESIZE THAT SPECIFIC AREAS OF THE GENOME ARE EPIGENETICALLY DYSREGULATED AS A RESULT OF SPACE TRAVEL, AND THAT SOME OF THESE AREAS DIFFER BETWEEN ASTRONAUTS. MOREOVER, WE HYPOTHESIZE THAT THE ENRICHMENT OF NON-CODING VARIANTS IN DISTINCT BIOLOGICAL PATHWAYS WILL ALSO DIFFER BETWEEN ASTRONAUTS, AND ANALYSIS AND INTEGRATION OF THESE DATA WILL REVEAL THE FIRST REGIONS OF "EPIGENETIC SPACE RISK" FOR THE ASTRONAUTS, DELINEATED IN BMED5. TO VALIDATE THESE PREDICTIONS, WE WILL PERFORM SINGLE-CELL ATAC-SEQ (ASSAY FOR TRANSPOSASE ACCESSIBLE CHROMATIN) ON CELL FRACTIONS FROM EARTH-BASED CONTROL SAMPLES AND THOSE TAKEN FROM SPACE. (3) SPECIFIC AIMS AIM 1. CREATE A WEB-BASED FRAMEWORK FOR INTEGRATING NON-CODING GENOMIC VARIATION AND DIFFERENTIAL EPIGENETIC STATES. THIS EPISUITE INTERFACE AND SET OF MACHINE-LEARNING ALGORITHMS WILL HELP ONGOING WORK WITH THE NASA TWINS STUDY AND AID FUTURE INVESTIGATIONS THAT LEVERAGE MULTI-OMICS DATA SETS FROM ASTRONAUTS. THESE DATA WILL ALSO BE LINKED TO GENE EXPRESSION DATA TO GAUGE THE IMPACT OF GENETIC AND EPIGENETIC CHANGES ON SPECIFIC BIOLOGICAL NETWORKS. AIM 2. VALIDATE THE ALTERED CHROMATIN STATES IN CELLS FROM SPACE TRAVEL AND MEASURE THE PROPORTION OF CELLS CHANGED WITH SINGLE-CELL ATAC-SEQ. WE WILL USE AN ASSAY CALLED SINGLE CELL (SCATAC-SEQ), WHICH CAN MEASURE THE SITES OF OPEN AND CLOSED CHROMATIN ON A CELL-BY-CELL BASIS. THIS WILL VALIDATE THE SITES WHERE WE OBSERVE EPIGENETIC CHANGES AND ALSO PROVIDE THE FIRST ESTIMATE OF THE PROPORTION OF CELLS EPIGENETICALLY IMPACTED BY SPACE TRAVEL. | WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $100,000 | NATIONAL AERONAUTICS AND SPACE ADMINISTRATION | NATIONAL AERONAUTICS AND SPACE ADMINISTRATION | — | — | AR21 | Feb 7, 2017 | Oct 26, 2016 | Oct 25, 2018 |