Cap-dependent endonuclease inhibitors (CENis) - NHRC
Contact and place of performance
Brian Kinkade
Galveston, TX
USA
The preclinical development of Cap-dependent endonuclease inhibitors (CENi), a class of small molecules, as broad-spectrum antiviral therapeutics. The scope of this project includes all activities required to select lead CENi candidates, including in vitro and in vivo efficacy studies and characterization and optimization of lead compounds. This includes Research Support expertise regarding the preclinical development of cap-dependent endonuclease inhibitors (CENis) with viruses that require biosafety level 4 (BSL-4) containment to support the Naval Medical Research Command in Fort Detrick, MD. This work will be performed over a 36-month period.
The Naval Supply Systems Command (NAVSUP) Fleet Logistics Center Norfolk, on behalf of the Naval Health Research Center (NHRC), is seeking research support services for the preclinical development of Cap-dependent endonuclease inhibitors (CENis). This project focuses on developing small molecule CENis as broad-spectrum antiviral therapeutics and involves all activities necessary to select lead candidates, including in vitro and in vivo efficacy studies as well as the characterization and optimization of lead compounds. The work requires specialized research expertise regarding viruses that necessitate biosafety level 4 (BSL-4) containment to support the Naval Medical Research Command in Fort Detrick, Maryland.
This requirement is identified under solicitation number N0018926QB059 and classified under NAICS code 541715, Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology), and PSC AN42, Health R&D Services; Health Care - Other; Applied Research. The procurement is designated with no set-aside (NONE). Performance will take place in Galveston, Texas, over a 36-month period.
Responses for this combined synopsis/solicitation are due by May 28, 2026. Documentation associated with this notice includes the original solicitation and combined synopsis, a performance work statement, and one solicitation amendment. The primary point of contact for this requirement is Brian Kinkade.
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