Research Opportunity: DNA-Protein Epigenetic Chemistry Engineering (D-PECHE) | SAM.gov Opportunity | G2X

Research Opportunity: DNA-Protein Epigenetic Chemistry Engineering (D-PECHE)

SolicitationDARPA-SN-26-67Notice typeSpecial Notice

Attachments

2 files

Name	Type	Posted	Actions
DARPA-SN-26-67-Amendment-01.pdf	PDF	May 18, 2026	Download
DARPA-SN-26-67.pdf	PDF	May 6, 2026	Download

Version History

Research Opportunity: DNA-Protein Epigenetic Chemistry Engineering (D-PECHE)

Special NoticeDARPA-SN-26-67May 18, 2026 · v2

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Opportunity Summary

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the DNA-Protein Epigenetic Chemistry Engineering (D-PECHE) program to demonstrate proof-of-concept for novel mechanisms for writing and erasing epigenetic base modifications in DNA. This research opportunity focuses on developing technologies to modify nucleic acids in vitro, providing new methods to control DNA-protein interactions and investigate the functions of rare or novel epigenetic modifications. This effort is classified under NAICS 541714 for Research and Development in Biotechnology (except Nanobiotechnology) and PSC AC11 for National Defense R&D Services; Department of Defense - Military; Basic Research.

The solicitation is managed by Dr. Aric Lu of the DARPA Biological Technologies Office (BTO) under solicitation number DARPA-SN-26-67. Responses are due by June 24, 2026. Amendment 1, issued on May 18, 2026, serves to clarify specific submission instructions and deadlines. Documentation for this notice includes the original special notice and the first amendment, both provided as PDF attachments.

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Opportunity Summary

Opportunity Details

Response deadline: Jun 24, 202612 days remaining
NAICS: 541714 (opens in new tab)
PSC: AC11 (opens in new tab)
Set aside: —
Published: May 6, 2026
Updated: May 18, 2026
Agency: DEPARTMENTAL OFFICES (opens in new tab)
Office: INVALID
Department: —
Source: View on SAM.gov (opens in new tab)

Contact and place of performance

Point of contact: Dr. Aric Lu, DARPA/BTO

Place of performance: Not specified

Original Description

UPDATE: The purpose of Amendment 1 to DARPA-SN-26-67, the DNA-Protein Epigenetic Chemistry Engineering (D-PECHE) Special Notice (SN), is to clarify submission instructions and deadlines.

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals to demonstrate proof-of-concept for novel mechanisms for writing and erasing epigenetic base modifications in DNA. Mechanisms capable of modifying the epigenome offer new opportunities to control DNA-protein interactions and to study the functions and applications of rare or novel epigenetic modifications. This research opportunity will result in demonstrations of novel technologies to modify nucleic acids in vitro.