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TECHNOLOGY LICENSING OPPORTUNITY: SurfGraphPro
Contact and place of performance
Caleb Ledgerwood
Los Alamos, NM 87545
USA
SurfGraphPro, an AI tool, transforms complex protein structures into an easy-to-analyze format that helps researchers quickly identify binding sites, predict molecular interactions and understand protein behavior with greater speed and scalability than traditional approaches. By combining 3D surface graph representations with advanced machine learning, this technology from Los Alamos National Laboratory reduces the c...
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SurfGraphPro solves these problems by converting protein surfaces into a graph-based representation that preserves both the physical shape of the surface and the biochemical information carried by surface-exposed amino acids. This tool gives machine learning models a more efficient and flexible way to process protein structures without requiring repeated manual feature engineering or highly specialized analysis pipelines for each new use case. By reducing computational burden while keeping the key structural details needed for prediction, SurfGraphPro makes it possible to analyze proteins more quickly, at larger scale and across a wider range of applications. This approach includes identifying likely binding sites, estimating molecular compatibility, supporting drug screening efforts, improving antibody and protein design workflows, and enabling other protein-focused prediction tasks where speed, scalability and adaptability matter.
Key Advantages:
Market Applications:
Development Status: TRL 3
US Patent pending
LA-UR-26-23589
LANL Tech Partnerships: Unlock the Innovative Potential
Los Alamos National Laboratory offers a wide range of cutting-edge technologies and capabilities that may provide your company with a competitive edge in the market and unlock the innovative potential that can enhance, refine, and revolutionize your products.
LANL’s licensing program focuses on moving inventions developed by our researchers to commercial innovations. Patented and patent pending inventions and copyrighted software are available to existing and start-up companies through exclusive and non-exclusive licensing agreements. For specific discussions, please contact [email protected].
Note: This is not a call for external services for the development of this technology.
https://www.lanl.gov/engage/collaboration/feynman-center/partner-with-us/licensing-technology
m.lanl.gov/tech-search
The Department of Energy, through Triad National Security, LLC at Los Alamos National Laboratory, is offering a technology licensing opportunity for SurfGraphPro under solicitation number S-196061. This artificial intelligence tool converts complex, three-dimensional protein structures into graph-based representations to identify binding sites, predict molecular interactions, and analyze protein behavior. By integrating surface graph representations with machine learning, the technology preserves structural and biochemical detail while reducing the computational burden associated with traditional analysis methods. The tool is currently at Technology Readiness Level (TRL) 3 with a U.S. patent pending (LA-UR-26-23589).
The technology is designed to enhance speed and scalability across various sectors, including pharmaceutical drug discovery, antibody engineering, pathogen detection, and agricultural biotechnology. SurfGraphPro eliminates the need for manual feature engineering or task-specific models, providing a flexible platform for protein-focused prediction tasks such as target screening and biomarker analysis. The licensing program offers these inventions to existing and start-up companies through exclusive or non-exclusive agreements to facilitate the transition of laboratory research into commercial innovation.
This special notice is classified under NAICS 541715 for Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) and PSC AJ11 for General Science and Technology R&D Services; General Science and Technology; Basic Research. No set-aside is applied to this opportunity. Responses are due by December 5, 2026, and the primary point of contact is Caleb Ledgerwood. The place of performance is located in Los Alamos, New Mexico.
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