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TECHNOLOGY LICENSING OPPORTUNITY: Peptoid-Based Chelating Ligands for Selective Metal Chelation
Contact and place of performance
Caleb Ledgerwood
Los Alamos, NM 87545
USA
Peptoid-based chelating ligands offer a tunable platform for capturing and holding specific metal ions with high selectivity while resisting breakdown under physiological conditions. The technology combines structural flexibility with strong binding performance, which creates a practical path for applications where existing chelators fall short, including difficult metal removal in biological, environmental and separ...
View moreThe invention describes cyclic peptoid ligands that can be built from linear peptoids and then cyclized, with the binding profile tuned through functional groups such as catecholates, phosphonates, amines, guanidinium groups, phosphoramidates, N-hydroxypyridones and CMPO-like groups. Linker length, hydrophobicity, hydrophilicity and the number of coordinating groups can be adjusted to improve selectivity for specific ions and to support either tight retention for removal or controlled release after capture.
Advantages
Market Applications
TRL 4
US Patent Nos. 11,254,708; 11,859,018
LA-UR-26-23913
LANL Tech Partnerships: Unlock the Innovative Potential
Los Alamos National Laboratory offers a wide range of cutting-edge technologies and capabilities that may provide your company with a competitive edge in the market and unlock the innovative potential that can enhance, refine, and revolutionize your products.
LANL’s licensing program focuses on moving inventions developed by our researchers to commercial innovations. Patented and patent pending inventions and copyrighted software are available to existing and start-up companies through exclusive and non-exclusive licensing agreements. For specific discussions, please contact [email protected].
Note: This is not a call for external services for the development of this technology.
https://www.lanl.gov/engage/collaboration/feynman-center/partner-with-us/licensing-technology
m.lanl.gov/tech-search
Triad National Security, LLC, a contractor for the Department of Energy, is offering a technology licensing opportunity for peptoid-based chelating ligands developed at Los Alamos National Laboratory. This technology utilizes cyclic peptoid scaffolds to capture and hold specific metal ions, particularly hard metal ions such as actinides and lanthanides, with high selectivity. Unlike traditional peptides, these peptoids feature side chains attached to nitrogen, providing increased resistance to hydrolysis and greater stability under physiological conditions or within harsh process streams. The modular design allows for the adjustment of ring size, side-chain chemistry, and linker length to support applications in environmental remediation, medical chelation therapy, imaging, and metal separations.
This special notice, identified by solicitation number S-133639, seeks commercial partners for exclusive or non-exclusive licensing agreements to transition these patented inventions into the market. The technology is currently at Technology Readiness Level (TRL) 4 and is associated with US Patent Nos. 11,254,708 and 11,859,018. The primary classification for this opportunity is NAICS 541714: Research and Development in Biotechnology (except Nanobiotechnology) and PSC 6632: Analysis Instruments, Medical Laboratory Use.
The performance location is Los Alamos, NM, and the response deadline for interested parties is June 30, 2026. There is no set-aside for this notice (Set-aside NONE). Administrative and technical inquiries are directed to the point of contact, Caleb Ledgerwood. This announcement is specifically for the licensing of existing intellectual property rather than a request for external development services.
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